Life Extension Immune Senescence Protection Formula, 60 veg tabs | 02005

Life Extension

SKU: 02005

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Immune Senescence Protection Formula™

Standardized Cistanche • Reishi • Pu-erh Tea

Comprehensive support for aging immune systems

60 vegetarian tablets 
Item# 02005


LE Certified Non-GMO

Life Extension researchers have developed a three-ingredient formula designed to combat immune senescence. Immune Senescence Protection Formula™ is composed of standardized Cistanche, reishi, and pu-erh tea extracts — three botanical ingredients that work to rejuvenate an aging immune system through innovative mechanisms.

Benefits at a Glance:

  • Helps rejuvenate an aging immune system
  • Supports immune system response to new invaders
  • Helps maintain a healthy naive-to-memory immune-cell ratio

More facts about Immune Senescence Protection Formula™

As we age, our immune system begins to decline, a process known as immune senescence.1 A vital immune system is made up of a healthy balance of naive T-cells that attack new invaders and memory T-cells that attack previously known invaders.

However, after a naive T-cell attacks a new threat, it becomes a memory T-cell, which will only go after a threat that it remembers.2,3 The result is that the delicate immune balance tips, so we have a surplus of memory T-cells and a deficit of naïve T-cells. Therefore our body is less able to defend itself against new invasions. This produces a less-vigilant immune system — or immune senescence.4,5

Cistanche rejuvenates an aging immune system

The echinacoside compound found in Cistanche plant extract stimulates the development of naive T-cells and leads to a lower number of memory T-cells, thereby creating a healthy immune response. Cistanche also increases natural killer (NK) cell activity — resulting in a 15% life span increase in those cells in pre-clinical research.6

A 12-week human study of standardized Cistanche yielded positive results in regard to immune profile: subjects had an 11.7% increase in NK cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells. An increased CD4-to-CD8 ratio is indicative of healthy, youthful immune function.7

Reishi mushroom combats immune senescence

The numerous bioactive components of the reishi mushroom exert powerful effects that may reverse many of the factors of immune senescence.8 Primarily, reishi extracts boost the function of innate immune cells, the immune system’s first line of defense.8-10

It has long been known that reishi’s unique polysaccharides, triterpenes, and other constituents11,12 enhance the body’s hematopoietic stem cells, T-cells, and other crucial immune factors.13-16 Animal research shows reishi supports multiple aspects of immune function and longevity.17-18

Pu-erh tea extract supports immune balance

Pu-erh tea is rich in polyphenols and other bioactive molecules. Pu-erh tea extract may support healthy bone marrow function, which helps to rebuild the peripheral immune cellular components.18

A pre-clinical study demonstrated that pu-erh tea extract supports a healthy immune response by decreasing interleukin-6 (IL-6) by a remarkable 43%, as well as increasing NK cells by 7% and naïve T-cells by 10%.20

Our Best-in-Class formula for immune system support

This one potent, triple-action formulation delivers Cistanche, Reishi and Pu-erh Tea. For year-round support of the aging immune system, add this Best-in-Class formula to your regimen today.


Supplement Facts

Serving Size 2 vegetarian tablets

Servings Per Container 30

Amount Per Serving

Calcium (as calcium carbonate)

175 mg

Reishi mushroom extract (fruit body) [std. to 13.5% polysaccharides, 6% triterpenes]

980 mg

Pu-erh tea extract (leaf) [providing polyphenols, theabrownin]

650 mg

Cistanche tubulosa extract (stem and leaf) [std. to 22% echinacosides]

210 mg

Shell-broken reishi mushroom (spore)

150 mg

Other ingredients: microcrystalline cellulose, starch, croscarmellose sodium, stearic acid, aqueous film coating (hypromellose, glycerin, purified water), hydroxypropyl cellulose, maltodextrin, silica, vegetable stearate.



Dosage and Use
  • Take two (2) tablets daily with food, or as recommended by a healthcare practitioner.
  • Each serving contains approximately 32.5 mg of caffeine (the amount found in about a 3/4 cup brewed green tea).
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.